22ª Matchday
| 23/01/21 | 16:00 | Rayo Vallecano - Mallorca | ||
| 18:15 | Girona FC - Espanyol | |||
| CD Lugo - Tenerife CD | ||||
| 20:30 | Malaga - Ponferradina SD | |||
| 24/01/21 | 14:00 | UD Almeria - CE Sabadell | ||
| 16:00 | UD Logrones - Real Oviedo | |||
| 18:15 | CD Castellon - Sporting Gijon | |||
| 20:30 | Las Palmas UD - CD Leganes | |||
| 25/01/21 | 21:00 | FC Cartagena - CD Mirandes |
League Table: Segunda Division
| # | Team | MP | W | D | L | F | A | D | P | Last 5 matches | ||||||
| 1 | Espanyol | 21 | 14 | 3 | 4 | 32 | 10 | +22 | 45 | W | L | W | W | W | ||
| 2 | Mallorca | 21 | 12 | 6 | 3 | 28 | 10 | +18 | 42 | L | D | L | W | W | ||
| 3 | UD Almeria | 20 | 13 | 2 | 5 | 28 | 15 | +13 | 41 | W | L | W | W | W | ||
| 4 | Rayo Vallecano | 21 | 11 | 4 | 6 | 24 | 15 | +9 | 37 | W | W | W | D | W | ||
| 5 | Sporting Gijon | 21 | 10 | 6 | 5 | 21 | 15 | +6 | 36 | W | D | D | W | L | ||
| 6 | CD Leganes | 20 | 10 | 4 | 6 | 19 | 14 | +5 | 34 | D | D | L | D | W | ||
| 7 | Ponferradina SD | 21 | 9 | 4 | 8 | 22 | 25 | -3 | 31 | D | L | W | L | D | ||
| 8 | Girona FC | 21 | 8 | 6 | 7 | 16 | 17 | -1 | 30 | D | D | L | D | W | ||
| 9 | Las Palmas UD | 21 | 7 | 8 | 6 | 22 | 25 | -3 | 29 | W | W | L | D | D | ||
| 10 | CD Lugo | 21 | 7 | 7 | 7 | 19 | 19 | +0 | 28 | D | D | L | W | D | ||
| 11 | Fuenlabrada | 22 | 6 | 10 | 6 | 22 | 23 | -1 | 28 | D | L | D | W | L | ||
| 12 | Malaga | 21 | 7 | 7 | 7 | 20 | 27 | -7 | 28 | D | D | D | L | L | ||
| 13 | Real Oviedo | 21 | 6 | 9 | 6 | 25 | 22 | +3 | 27 | D | D | L | W | W | ||
| 14 | CD Mirandes | 21 | 7 | 6 | 8 | 18 | 18 | +0 | 27 | L | L | L | W | D | ||
| 15 | UD Logrones | 21 | 8 | 3 | 10 | 18 | 26 | -8 | 27 | L | W | D | L | L | ||
| 16 | Tenerife CD | 21 | 7 | 5 | 9 | 19 | 20 | -1 | 26 | W | W | W | L | D | ||
| 17 | Alcorcon AD | 21 | 5 | 6 | 10 | 12 | 18 | -6 | 21 | D | L | W | D | D | ||
| 18 | CE Sabadell | 21 | 5 | 5 | 11 | 19 | 26 | -7 | 20 | D | D | D | W | D | ||
| 19 | FC Cartagena | 21 | 5 | 5 | 11 | 23 | 31 | -8 | 20 | L | D | L | L | W | ||
| 20 | CD Castellon | 21 | 5 | 4 | 12 | 18 | 28 | -10 | 19 | L | L | D | W | L | ||
| 21 | Real Zaragoza | 22 | 4 | 6 | 12 | 14 | 22 | -8 | 18 | L | W | D | W | L | ||
| 22 | Albacete Balompie | 21 | 4 | 6 | 11 | 13 | 26 | -13 | 18 | W | D | W | L | L | ||
