31ª Matchday
| 14/04/21 | 19:00 | Rayo Vallecano - CD Mirandes |
35ª Matchday
| 16/04/21 | 19:00 | Fuenlabrada - CE Sabadell | ||
| 21:00 | Girona FC - Real Zaragoza | |||
| 17/04/21 | 14:00 | CD Lugo - Alcorcon AD | ||
| 16:00 | CD Castellon - Mallorca | |||
| 18:15 | Sporting Gijon - Real Oviedo | |||
| Las Palmas UD - Malaga | ||||
| 18/04/21 | 14:00 | Albacete Balompie - CD Mirandes | ||
| UD Logrones - Rayo Vallecano | ||||
| 18:15 | FC Cartagena - Tenerife CD | |||
| 19/04/21 | 19:00 | CD Leganes - Ponferradina SD | ||
| 21:00 | UD Almeria - Espanyol |
League Table: Segunda Division
| # | Team | MP | W | D | L | F | A | D | P | Last 5 matches | ||||||
| 1 | Espanyol | 34 | 21 | 7 | 6 | 58 | 22 | +36 | 70 | W | W | W | W | W | ||
| 2 | Mallorca | 34 | 20 | 8 | 6 | 44 | 21 | +23 | 68 | W | D | W | L | D | ||
| 3 | UD Almeria | 34 | 18 | 6 | 10 | 49 | 31 | +18 | 60 | L | L | W | D | L | ||
| 4 | CD Leganes | 34 | 17 | 6 | 11 | 38 | 29 | +9 | 57 | L | W | L | D | L | ||
| 5 | Sporting Gijon | 34 | 15 | 11 | 8 | 35 | 24 | +11 | 56 | L | L | W | D | D | ||
| 6 | Rayo Vallecano | 33 | 16 | 7 | 10 | 41 | 31 | +10 | 55 | W | W | L | W | W | ||
| 7 | Girona FC | 34 | 13 | 10 | 11 | 34 | 34 | +0 | 49 | L | W | D | W | W | ||
| 8 | Ponferradina SD | 34 | 13 | 10 | 11 | 37 | 38 | -1 | 49 | D | L | D | D | W | ||
| 9 | Malaga | 34 | 13 | 9 | 12 | 32 | 38 | -6 | 48 | W | W | L | D | D | ||
| 10 | Las Palmas UD | 34 | 11 | 12 | 11 | 39 | 43 | -4 | 45 | D | D | W | D | L | ||
| 11 | Tenerife CD | 33 | 12 | 8 | 13 | 30 | 29 | +1 | 44 | W | L | D | D | W | ||
| 12 | CD Mirandes | 32 | 12 | 8 | 12 | 31 | 31 | +0 | 44 | L | W | L | D | L | ||
| 13 | Fuenlabrada | 34 | 9 | 16 | 9 | 36 | 37 | -1 | 43 | D | L | L | W | W | ||
| 14 | Real Oviedo | 34 | 8 | 16 | 10 | 35 | 35 | +0 | 40 | D | L | D | D | D | ||
| 15 | Real Zaragoza | 34 | 10 | 9 | 15 | 26 | 31 | -5 | 39 | W | W | D | D | W | ||
| 16 | UD Logrones | 34 | 10 | 9 | 15 | 25 | 42 | -17 | 39 | W | W | D | D | L | ||
| 17 | CD Castellon | 33 | 10 | 6 | 17 | 32 | 40 | -8 | 36 | W | W | L | D | W | ||
| 18 | CD Lugo | 34 | 8 | 12 | 14 | 29 | 42 | -13 | 36 | L | L | L | L | D | ||
| 19 | FC Cartagena | 34 | 8 | 11 | 15 | 34 | 45 | -11 | 35 | D | W | D | D | L | ||
| 20 | CE Sabadell | 34 | 7 | 12 | 15 | 30 | 40 | -10 | 33 | D | L | D | W | D | ||
| 21 | Alcorcon AD | 33 | 8 | 9 | 16 | 22 | 32 | -10 | 33 | L | D | D | L | D | ||
| 22 | Albacete Balompie | 34 | 7 | 8 | 19 | 21 | 43 | -22 | 29 | L | L | L | L | W | ||
